Analysis of the mutation dynamics of SARS-CoV-2 reveals the spread history and emergence of 2 RBD mutant with lower ACE2 binding affinity
Quick reaction without looking in any detail: the reportedly lower mutation rate for SARS-CoV-2 than SARS-CoV is surprising to me. Most surprising findings turn out to be wrong, but some of them don’t. The observation of a single sample with possibly lower ACE2 binding affinity is not surprising – it’s only if you see a functional mutation spreading that it becomes of clinical or epidemiological interest.
It seems to me that their sample size is too small to justify their conclusion.