Barry Hall's Life Story of Studying an Evolved Protein

I am familiar with Barry Hall’s work with the evolved beta-galactosidase gene, but I ran across a paper that is well worth reading. It is more or less a review paper of his own career. Here is the teaser paragraph from the beginning of the paper:

It is a dense and long article which I haven’t thoroughly read through, but it contains a more humanized story of how a scientist stumbles from one discovery to another, and how studying one enzyme can take up a career in one form or another. I thought there might be a few people here who would be interested in a longer read and good conversation on what they gleaned from it.