# Behe Meets the Peaceful Science Forum

**URL:** <https://discourse.peacefulscience.org/t/behe-meets-the-peaceful-science-forum/13294>\
**Category:** Public Square\
**Tags:** Science, Design, Society\
**Created:** [March 2, 2021, 11:03pm UTC](https://discourse.peacefulscience.org/t/behe-meets-the-peaceful-science-forum/13294 "2021-03-02T23:03:44Z")\
**Posts on this page:** 1\
**Showing post:** 34

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**Author:** ![sfmatheson](https://sea2.discourse-cdn.com/flex016/user_avatar/discourse.peacefulscience.org/sfmatheson/32/22811_2.png) [@sfmatheson](https://discourse.peacefulscience.org/u/sfmatheson)\
**Post date:** [March 6, 2021, 6:22pm UTC](https://discourse.peacefulscience.org/t/behe-meets-the-peaceful-science-forum/13294/34 "2021-03-06T18:22:55Z")

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> [@Giltil](#):
>
> Now, regarding the issue of whether some of the mutations found in polar bear APOB lead to loss of molecular function, why not using VIPUR, a method specifically designed for this purpose?

This tool was published 5 years ago and seems not to be widely used. (I haven’t checked Scopus but citation in PubMed Central has been sparse.) Looking at the citations in PMC, I see two very recent publications about similar tools. If someone wanted to do the “analysis” of this data set, they would have multiple up-to-date peer-reviewed tools at their disposal. Links below, starting with the final peer-reviewed version of the VIPUR paper. See also [this previous discussion](https://discourse.peacefulscience.org/t/revisiting-polar-bears-evolution-news/6005/22) of the tools (in 2019) and their effectiveness.

> **[Robust classification of protein variation using structural modelling and...](https://academic.oup.com/nar/article/44/6/2501/2499465)**
>
> Abstract. Existing methods for interpreting protein variation focus on annotating mutation pathogenicity rather than detailed interpretation of variant deleteri

> **[Mutation severity spectrum of rare alleles in the human genome is predictive...](https://journals.plos.org/ploscompbiol/article?id=10.1371%2Fjournal.pcbi.1007775)**
>
> Author summary Human genetic variations in various forms are constantly found in whole genome and exome sequencing of general population and patients. It remains a challenging task to assess the functional impact of these variations. In this study,...

[https://www.pnas.org/content/117/45/28201.long](https://www.pnas.org/content/117/45/28201.long)

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