# Gpuccio: Functional Information Methodology

**URL:** <https://discourse.peacefulscience.org/t/gpuccio-functional-information-methodology/7549>\
**Category:** Conversation\
**Tags:** Science, Design\
**Created:** [August 25, 2019, 1:33am UTC](https://discourse.peacefulscience.org/t/gpuccio-functional-information-methodology/7549 "2019-08-25T01:33:24Z")\
**Posts on this page:** 1\
**Showing post:** 47

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**Author:** ![swamidass](https://sea2.discourse-cdn.com/flex016/user_avatar/discourse.peacefulscience.org/swamidass/32/3_2.png) [@swamidass](https://discourse.peacefulscience.org/u/swamidass)\
**Post date:** [August 26, 2019, 2:46pm UTC](https://discourse.peacefulscience.org/t/gpuccio-functional-information-methodology/7549/47 "2019-08-26T14:46:51Z")

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You can feel free to refine your case, as long as you are clear about any shifts you are making.

Three questions:

1. What empirical evidence do you have that demonstrates FI increases are unique to design?

2. How have you accounted for the similarity between proteins due to common descent?

3. How have you accounted for differences between proteins caused by neutral drift and neutral coevolution?

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