# Nathan Lents at CFI: ID and Science Denial

**URL:** <https://discourse.peacefulscience.org/t/nathan-lents-at-cfi-id-and-science-denial/11747>\
**Category:** Public Square\
**Tags:** Science\
**Created:** [September 16, 2020, 1:13am UTC](https://discourse.peacefulscience.org/t/nathan-lents-at-cfi-id-and-science-denial/11747 "2020-09-16T01:13:04Z")\
**Posts on this page:** 1\
**Showing post:** 41

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**Author:** ![Art](https://sea2.discourse-cdn.com/flex016/user_avatar/discourse.peacefulscience.org/art/32/3805_2.png) [@Art](https://discourse.peacefulscience.org/u/Art)\
**Post date:** [September 25, 2020, 1:09pm UTC](https://discourse.peacefulscience.org/t/nathan-lents-at-cfi-id-and-science-denial/11747/41 "2020-09-25T13:09:47Z")

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> [@NLENTS](#):
>
> I’ll drop a blog post later today or Monday and spread more credit around for the polar bear work.

This thread was also very interesting:

> [@Repeating analysis of human APOB](https://discourse.peacefulscience.org/t/repeating-analysis-of-human-apob/5734):
>
> While studying how Polyphen-2 works, I noticed that one of its features is to use a sequence comparison to help assess the effect of a mutation in a human protein. This made me wonder if the polar bear gene was included as a homolog in the analysis back before the 2014 Liu paper was published. Further I wondered if any new data has come out or any new updates would allow a new prediction by Polyphen for the exact same polar bear mutations. Basically, let’s repeat the Polyphen analysis for the following “damaging” mutations: Gene Position Ancestral Polar bear HDivPred APOB 716 N K possibly damaging APOB 749 D E possibly damaging APOB 2623 D N probably damaging APOB 3920 T P possibly damaging APOB 4418 L H probably damaging [716-alignment] It is predicted exactly the same, which makes it seem like nothing has changed since it is giving the exact same probability to 3 decimal places. We can see the homologs used in the alignment, but I did not find…

Basically, none of the variants being discussed found their way into the finished polar bear genome.

This whole episode was/is a great example of teamwork - many participants here contributed.

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