Predicting the evolution of genetic mutations

Described in Nature Communications , the algorithm called “minimum epistasis interpolation” results in a visualization of how a protein could evolve to either become highly effective or not effective at all. They compared the functionality of thousands of versions of the protein, finding patterns in how mutations cause the protein to evolve from one functional form to another.

And the Nature Communications article:

https://www.nature.com/articles/s41467-020-15512-5

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Really interesting work! Thanks!

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“Wow! They did that?”, Was my first thought. I need to give this a careful read.