The claim is well supported you just don’t understand the evidence as you misuse the sharpshooter fallacy.
Many proteins are preserved this is a fact. This is evidence of limited functional sequence space.
That’s an assertion in need of evidence and coherent argument.
So is that.
So is that.
Where DNA sequences are changing and AA sequences are preserved over long periods of time the functional space is limited. If the functional space was not limited we would not see this pattern.
A sure tell Bill is floundering is when he tries to turn criticisms of his position he can’t answer back at the pro-science side.
Just like having one number in a million win the lottery is evidence of a limited winning number space, right Bill?
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How limited Bill? How do you know?
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There’s your problem. Your premise is not connected to your conclusion. That, and you confuse the functional space (the sequences visible to selection) with the adaptive peak.
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Bare assertions.
No one doubts that there is limited functional sequence space. What you haven’t shown is that it is too limited for evolution to work.
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No, it isn’t.
Why can we find multiple immunoglobulins with beta-lactamase activity in a library of only 10^8?
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An adaptive peak is evidence of limited functional space. Are you claiming that all proteins have adaptive peaks?
Everyone agrees that there is limited functional space. What we don’t agree with is your claim that functional space is so limited that evolution would not be able to produce the biodiversity we see today.
No, it isn’t. While functional space is limited, this isn’t evidence of any limitation whatsoever.
Why can we find multiple immunoglobulins with beta-lactamase activity in a library of only 10^8?
HOW LIMITED Bill? HOW DID YOU DETERMINE THE LIMITS?
Those are the questions you won’t address for love nor money.
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No it isn’t. Once again you confuse the peak with the slope. A mountain has a peak, but not all the mountain is the peak, and you can climb to the peak starting from the base.
It’s unclear what you mean by that, so I’m unable to answer.
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With a 2500 AA protein there can be lots of function yet this does not matter as the total sequence space makes evolution exceeding unlikely. This is just one of 170 proteins that are required to splice out introns inside a eukaryotic nucleus. You don’t have a viable mechanism that can find this function. In this case there is no hill to climb you can either splice out the introns or the organism dies.
In addition you have the chicken and egg problem that the proteins require the complex it is part of to produce itself.
Have you found a protein with this type of landscape?
Why?
How did you determine that there are not other proteins outside of those 170 proteins that could splice out introns? How did you determine that intron splicing had to evolve?
Another of your conceptual problems is that you look at the current interdependent state of a system and assume it had to be like that from the beginning. Why?
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Again, no way to figure out what you mean.
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Different proteins have different functions. Enzymes have adaptive peaks do kinesins, or ubiquitin proteins/
I don’t assume this. I do base conclusions on what is being observed versus making up a story.