Hey Brian, why are you repeating previous falsehoods in your response to Jerry Coyne? You repeat the falsehood that accumulating mutations in proteins inevitably destabilize them, and cite the work of Dan Tawfik to substantiate that point:
Recent work by Weizmann Institute protein scientist Dan Tawfik has reinforced this conclusion. Tawfik’s work shows that as mutations to functional protein sequences accumulate, the folds of those proteins become progressively more thermodynamically and structurally unstable. Typically, 15 or fewer mutations will completely destroy the stability of known protein folds of average size.
But I have personally corrected you on that falsehood on this website now twice . You have not responded to either of my corrections at all.