How can you reject that? I see we’re right back to discussing that subject you left off here. So now you’re claiming to be back with the premises needed to complete this argument?
Premise 1: PRPF8 is highly conserved. Check!
Premise 2: Sequence space for proteins of that length is 20^L, which is a very large number. Check!
Premise 3: The total number of functional sequences is less than the total sequence space. Check!
Premise 4: There is no evidence of lower fitness PRPF8 alleles.
Premise 5-?: (…)
Conclusion: Therefore it is highly doubtful, or impossible, that PRPF8 could have evolved.
So what are these new premises you have discovered since January 17th?