I am going to posit something you are not ready for and will not like. But of the four forces of evolution
–Natural selection, Genetic drift, Gene flow, Mutations–
…only one may in fact be the single and authentic force – namely, natural selection. Simplistically speaking, as environment impinges on the sensory areas of the brain (or neuron cluster depending the organism), the brain continually processes new information received and directly drives any and all changes to DNA, gene variation, migration, destruction, survival, etc.
With the brain in control, neuro-commands to DNA are deliberate based on outside information received. Nothing is random or left to chance. As well, with the brain as the driving force of organism survival and change, one would have to prove that it is the brain that is able to “macro-evolve” before macroevolution could even be remotely viable.
In short, this would mean that evolutionists are looking in the wrong place to validate their hypotheses. In focusing on DNA and genes, they are looking at the end product of information flow rather than the source – that is, the brain.
(edit: changed “authenticate their hypotheses” to “validate their hypotheses” in 2nd to last sentence)