Are Mutations Random With Respect to Function?

[swamidass (S. Joshua Swamidass)]

@John_Harshman, please read the whole thread carefully before you comment. I explained already a well established point.

@swamidass

In the case of transitions/transversions, actually, we know that this is the case. Transitions are more common, and are more likely be beneficial than transversions. That means that the transition/transversion imbalance skews mutations to beneficial ones, much more than we would expect from a uniform distribution.

If you dispute this, we can take that up in a different thread.