This is a list of seventeen genes described in Liu et al. as being affected by missense mutations, and their classification according to computer predictions. I have made four groupings here so that readers can see how the computer predictions sort out: those genes whose associated misssense mutations are all benign, those bearing either benign or “possibly damaging” mutations, those with at least one “probably damaging” mutation, and those with missense changes are predicted to give differing outcomes (and may have only benign or possibly damaging mutations). Readers are invited to look into, and comment on, these, and especially on the prospects that these may be degraded or destroyed in the polar bear.
Benign:
EHD3
OR5D14
SH3PXD2B
Possibly damaging:
ABCC6
POLR1A
Probably damaging:
APOB
COL5A3
CUL7
LAMC3
LYST
OR8B8
VCL
Conflicting prediction:
AIM1
ARID5B
IPO4
TTN
XIRP1