Below are the parameters. The second parameter ^ , the 4th P and the 5th parameter o will determine how many mutations will be required to get a likely functional mutations. The functions in the model are disulfide bonds and ligand binding functions.
N | Number of organisms/duplicate genes in the population |
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λ | Number of initially incompatible nucleotide loci in a duplicate gene that must be changed to form the selectable, multiresidue feature |
v | Point mutation rate per nucleotide per generation |
ρ | Ratio of the number of possible mutations of the original duplicated gene that would produce a null allele to the number of possible mutations of the original duplicated gene that would yield a compatible residue. Neutral mutations, such as those that produce synonymous codons, are disregarded. |
ϕ | Fraction of a particular nucleotide position that is in the incompatible state. (1 - ϕ) is the fraction in the compatible state. |
t | Time, in generations |
Tf | Time in generations to the first occurrence of a particular multiresidue, selectable features |
Tfx | Time in generations to fixation in the population of a particular multiresidue, selectable feature |
s | Selection coefficient |