No. Only something divine or at least a partial Halting Oracle could result in something so precise and improbable.
Actually: The hisO1242 mutation was originally isolated around …
OOPS! MY BAD! It was isolated previously as Art mentioned…
It’s just a deletion of about 35 bases. John Roth’s group sequenced the mutation in 1980 and determined why it likely worked. A number of deletion mutations through that region would probably work as well.