DNA duplication, mutation, and information

[Michael_Okoko]

@scd

@Michael_Okoko

Yes its “just” promoters that evolved, but they evolved from nonfunctional, random DNA sequences in approximately two weeks

since DNA isnt a protein this is irrelevant. we are talking about proteins, which are different from DNA in few ways.

Nice try shifting the goal posts. We have being talking about the evolution of new functions regardless of whether they emerge in proteins or nuclei acids.

@scd

@Michael_Okoko

This contrasts with the unrealistic high improbability arguments you keep throwing about here.

i never said that every function is isolated in sequence space. but i do think that many of them are probably are, such as that repressor:

https://onlinelibrary.wiley.com/doi/abs/10.1002/prot.340070403

“Nevertheless, the estimated number of sequences capable of adopting the h repressor fold is still an exceedingly small fraction, about one in 10^63 of the total number of possible 92-residue sequences

This papers showed the extremely low probability of getting a lambda repressor FOLD from its 92-residue sequences if we were to build it from randomly chosen amino acids as done in the study. It says nothing about the evolution of new FUNCTIONS, like a repressor function.