Dr. Joshua Swamidass and TMR4A: Some Major Modeling Problems for Young Earth Creationism

Look at what you listed:

Xue is included. Karmin is included. Helgeson is included. Francalacci, Poznik, Mendez are referenced.

And he discusses those papers and their methods.

This was made even more clear in how Karmin et al. (2015) defined the accuracy of their filtering strategy: “The number of FS [i.e., Father-Son] differences was approximately 10-fold higher than the expected number of de novo mutations considering the range of published Chr Y mutation rates (Xue et al. 2009; Francalacci et al. 2013; Mendez et al. 2013; Poznik et al. 2013). This finding prompted us to explore additional filters” (page 4 of the Supplementary Information). Of the four studies they cited—Xue et al. 2009; Francalacci et al. 2013; Mendez et al. 2013; Poznik et al. 2013—only the Xue et al. study represented a pedigree-based Y chromosome mutation rate. The other three studies derived a mutation rate via the historically circular evolutionary geology-based molecular clock method—see Introduction—or by extrapolating the autosomal mutation rate onto the Y chromosome.

1 Like