My reading of Behe was that he’s using papers like Summers et al. (2014) to conclude that the “improbable part” really is 2 specific point mutations, and after that the optimisation comes easily. If that’s the case, then it doesn’t matter how many genes or mutations are involved in the optimisation process, the estimate from the article of 10^20 is, say, 99% driven by those 2 mutations, and 1% by the other optimising mutations.
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