Gil's testable ID hypothesis

[Giltil (Gilbert Thill)]

@Rumraket

It has most of the sequence, not functional information

It is exactly what I said for I explicitly recognized that a system (or a sequence) unable to perform the function has zero FI.

@Rumraket

Most of the sequence required is there.

If most of the sequence required is there, it means that it has almost all the necessary bits of information to implement the function.

@Rumraket

Functional information is an abstraction that relates only to some minimum level of function, the sequence is an actual molecule, and you keep getting the two confused.

I really don’t understand your feud here.
@gpuccio has learned us that « FI is a property of the function, the minimal number of specific bits necessary to implement the function ». A given sequence of aa can or cannot implement the function. If it can, it means that it has all the specific bits necessary to perform the function. If it can’t, it means that one or more bits is missing. In my example of the CFTR mutant, the right aa is missing at position 508, meaning that the mutant CFTR lack 4,3 bits to perform the function.

@Rumraket

Yeah I’m afraid that’s just wrong. The process of recombination or mutation is what creates the FI

You’re wrong here. To see this, please consider my example of the mutant CFTR gene. Would you say that by reversing the Pro into a Phe at position 508 the physicians would have generate an amount of information equal to the FI of the functional CFTR?

@Rumraket

To illustrate this point, let’s take the example of cystic fibrosis. Cystic fibrosis is caused by mutations in both copies of the CFTR gene. Imagine that one of the copie of the CFTR gene of a given patient is characterized by a single mutation resulting in say a Phe to Pro transition at position 508 of the protein and that this change in the protein completely abolishes it’s function.
Imagine now that to cure this patient, the physicians decide to correct the mutation, reversing the Pro into a Phe at position 508. Thanks to gene editing technologies, such a thing may not be science fiction anymore.

https://www.cff.org/Research/Research-Into-the-Disease/Restore-CFTR-Function/Gene-Editing-for-Cystic-

In the above situation, the FI of the defective protein would be zero, for the protein doesn’t perform its function. But I hope it is clear for everyone here that the defective protein has already almost all the specific bits of information in place for performing the function so that the amount of information that must be infuse by the physicians to cure the patient is only 4,3 bits at most.

It has the sequence, not the functional information. You are again confusing sequence with functional information

Function is a possible attribute of a sequence. Indeed and again, a sequence can implement a function or not. If it can, then it has all the FI, ie, all the specific bits necessary to implement the function.