Gil's testable ID hypothesis

[Giltil (Gilbert Thill)]

@Mercer

You may then isolate from that same person a number of naïve B-cells and for each of them determine the sequences of the V regions of the cognate B cell receptor. Then, you may blast the sequences of the V regions determined in the different B cells against the sequence of the genome determined in the stem cell.

OK, but the V regions of naïve B-cells do not include the additional variation and refinement that we all know produces increased antibody function. So aren’t you missing a lot of differences?

Why are you blaming me for focusing only on VDJ recombination when it is you that challenge me on this very topic?

Is ID science? Redux

That is the truth. Purely natural processes are actually capable of producing high FI in that antibodies are evolved in only two weeks. Both you and gpuccio have tried to pretend that only one process (somatic hypermutation) is producing FI, while ignoring V(D)J recombination. Didn’t @gpuccio claim that he was going to do an analysis of antibody evolution? Whatever happened to that, Gil? Did he not get the answer he was hoping for?

So no, I am not missing « the additional variation and refinement that we all know produces increased antibody function », I am simply responding to the point that you yourself put on the table.