IMO doxycycline is a better bet than the malaria prophylactics that make you crazy.
Yes, and given the number of physicians trying it, the bias against publishing negative results, and our incredible ability to fool ourselves, at this point absence of evidence strongly indicates evidence of absence.
At this point, we have to keep in mind that 1 of every 20 studies that is properly done will find a therapeutic effect with a p of 0.05, so we can be statistically certain that such studies will be published.