Intelligent design and "design detection"

[Mercer (John Mercer)]

@Giltil

@John_Harshman

@Giltil

Gpuccio uses BLAST results as a proxy for FI as defined by Szostak.

As pointed out already by many, it’s a ridiculous and invalid proxy

This may be seen as a non sequitur!

By whom? Everyone posting here agrees. You even admitted that it is spurious as a proxy.

@Giltil

It would be better if you could explain why you think Gpuccio’s proxy of FI as developed at 39 of the thread we are discussing is spurious.

I have already done so in great detail in a thread in which YOU claimed that it was part of the definition.

I’ll repeat my generous offer to you from 2 years ago. Why did you not even acknowledge it?

Jul '21

@Mercer

@Giltil

The bindings involve in complex functional proteins such as DNA polymerases or ligand-gated ion channels are not mere unspecified bindings, but highly fine tuned, integrated, coordinated and regulated bindings which can only be established within large proteins exhibiting high functional information.

If it’s that fine tuned, how was it that my colleagues and I could change the specificity of two of the most complex proteins known (myosins) without a significant effect on their normal functions, merely by changing a single amino-acid residue in the active site to one not found in nature?

If you are correct, we could not possibly have succeeded. Link to 5 papers below:

So, Gil, shall we go through these papers together?