It’s true that GE is not formulated in terms of physics or information theory, but Sanford didn’t call it Genetic Decay, he called it Genetic Entropy. I think it’s apparent he equates the loss of genetic information through deleterious mutations to entropy.
To make the connection between GE and the 2LoT argument would require Sanford to define what he means by “information”. He won’t do that, of course, because then GE automatically fails. You may recall this previous discussion on the unwillingness of Creationists to define information.
I should mention that Sanford probably doesn’t know how to define information in the context of GE. I’m pretty sure and definition in terms of Shannon Information would show the whole concept is invalid.
I wonder if there might be a proof of that …