The idea that breaking a bond in the backbone of a polypeptide or genetic polymer is guaranteed to also instantly render it completely nonfunctional is also wrong. Proteins are known to be able to retain their structures with backbone damage because the secondary structural elements are keeping the ensemble together. Even if you break a peptide bond somewhere in a stack of beta sheets, it is entirely possible the sheets can still hold the structure together. You could also extend this principle to consider multi-domain proteins that have evolved by domain acquisition, and each domain is basically independently folding and functional even if removed from the context of the neighboring domains. So splitting these proteins up into individual parts can still retain their functions depending on where and how you do it.
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