Agreed. @DaveB, do you know of any exceptions? Let’s get a prediction from “ID Theory.”
I have a library of random, 110-residue protein sequences that are juxtaposed essentially as dimers, but very constrained to fit in (and not disrupt) a particular structural motif–the immunoglobulin fold.
@DaveB, how many of those dimers do you predict that one would have to screen to get immunoglobulins with measurable beta-lactamase activity?
@DaveB, do you now see the circularity of your argument?