We are not going to have a mutation-by-mutation pathway for every single protein over the last 4 billion years, and it isn’t required. What we do have is plenty of evidence for many genes that carry the signature of RV + NS, including the evidence I already supplied:
We could also talk about phylogenetic signal, divergence of intron and exon sequence, and Ka/Ks ratios if you like. We find the signature of evolution throughout genomes.