That’s not entirely true. We humans use random mutation and selective pressures to get the outcomes we want. In fact, some of the earliest GMO crops were created by zapping plants with radiation and selecting for the features the scientists wanted. Perhaps God does guide every mutation, but there may be reasons why it wouldn’t be required in order to get the results God wants.
Is there anything in mainstream orthodoxy that says God guides every mutation? What role does free will play in all of this?