Ratio of Beneficial Mutations to Others

[cwhenderson (Curtis Henderson)]

@Giltil

I beg your pardon, but it is a matter of fact that deleterious mutations are immeasurably more numerous than beneficial ones, a good estimate being one million to one.

I strongly suspect that mutations that “break” genes do considerably outnumber those that add new function. But where did you come up with the 1,000,000:1 ratio? Is this published somewhere? It would be good to have data supporting your conjecture.