Ratio of Beneficial Mutations to Others

[Rumraket (Mikkel R.)]

@Giltil

But the point is precisely that I can cite all the damaging mutations I want, which you’d have a hard time doing for constructive ones because the former are immeasurably more numerous than the later.

No, they technically have to be exactly equal, because any mutation is in principle reversible. For any “damaging” mutation you can imagine, we can imagine the “damaged” state as ancestral and the “reversal” to the descendant as constructive.