Sponge Discussion

[Giltil (Gilbert Thill)]

@Michael_Okoko

@Giltil

IOW, during all the history of the fight between QC and Plasmodium falciparum , the bug has been able to find only one strategy or overall solution to resist chloroquine, a strategy moreover that does not involve the development of a new function but the modification of an existing one .

Incorrect. The ability of pfcrt to facilitate the efflux of CQ is a new function because wild-type pfcrt has no CQ-transport activity

It is you who is incorrect, for wild-type pfcrt seem to have CQ-transport activity.
https://www.pnas.org/content/112/11/3356