[quote=“Michael_Okoko, post:12, topic:14185, full:true”]
You are incorrect and you are the one who didn’t read the paper. Here is a relevant passage supporting the CQ transport activity of PfCRT3D7, the wild-type version of the protein:
Next, we investigated the mechanisms underlying the different responses between CQ-sensitive and CQ-resistant PfCRTs in cis -inhibition. We focused on CQ uptake by PfCRTs because oocytes of Xenopus laevis expressing resistant PfCRTDd2 were reported to take up CQ, whereas oocytes expressing CQ-sensitive PfCRT3D7 did not (16). In reconstituted liposomes, CQ-sensitive PfCRT3D7 showed significant uptake of CQ (Fig. 3 A and B ). However, CQ-resistant PfCRTs exhibited an increase in CQ transport activity in accordance with the degree of resistance, with that in PfCRTDd2 showing a threefold increase (Fig. 3 A ). Kinetic analysis of CQ uptake indicated that the increase in activity was due to a decrease in affinity to CQ (increase in K m value) and an increase in the V max of the transporter (Fig. 3 B and C ). Thus, the lack of an effect of CQ on TEA uptake in CQ-resistant PfCRTs was due to changes in kinetic properties. This implies that CQ is discharged from DV by PfCRT even in CQ-sensitive malaria parasites and that the amount of CQ discharged from DV is significantly increased in CQ-resistant variants.