Strong evidence that a search algorithm can find high functionality in an astronomically large search space

[Mercer (John Mercer)]

@colewd

@Mercer

We’re not talking about a mere “claim.” We’re talking about a robust theory that makes predictions, many of which involve mathematics that you clearly refuse to engage with, even the simplest ones.

How do you make the math work with the current empirical data?

What math and data did you use?

@colewd

If we want to show this is a general mechanism and not specific to bacteria the problem gets much worse with slower generation times and more complex protein functions.

I’m not seeing any problem.

Here are some data:

https://www.jbc.org/action/showFullTableHTML?isHtml=true&tableId=tblII&pii=S0021-9258(19)51632-5

So how do you define a “single function” given data like these?

@CrisprCAS9

@colewd

This is less than one per gene over 30 years and is after 50000 generations.

If you think fixation is relevant to search, you don’t understand what those words mean.

Exactly.