Okay. What has held it over the last 11 years is basically all of it. If some small notion of it has been made obsolete from new research, I don’t know what it is.
Shapiro’s main thrust is that if the first life required a large molecule like DNA or RNA, then abtiogenesis is a lost cause. That approach requires a miracle. This is has not changed. There is nothing in the research since 2007 that makes even a smallish DNA molecule more likely that it was when this was written.
In fact, additional research has shown that Shapiro is exactly right. In 2010, Craig Venter and his team created the first synthetic life. They created synthetic DNA of a bacterium and inserted into a living cell and the cell continued to thrive and reproduce. That’s a remarkable achievement. What is even more interesting is that the first time they tried, there was a mistake and the cell died. They looked to see what happened and realized the DNA had 1,000,000 letters (A,C,G, and T) in the molecule, but one of them was wrong. Just one wrong letter out of a million and the cell died. This shows that DNA cannot just be slapped together haphazardly and live.
If you would like to disagree with this, if you believe something has materially changed, I would like to see your evidence.