Behe’s book as resulted in a lot of attention being focused onto one gene: ApoB. I thought it might be useful for the scholars here at PS to do some background work on what ApoB does, what effects mutations may have, and possibly what effects the specific changes in the polar bear ApoB gene may have.
I found a useful review article:
It would appear that ApoB has two main functions: getting cholesterol into the blood stream and getting it out of the blood stream. Therefore, high or low levels of lipids in the blood stream can be affected by lipid production and lipid clearance. I have only briefly skimmed the abstract of the paper and thought it would be a great topic for the scholar forum.
Interestingly, ApoB is found in two isoforms through post-transcriptional modification: apoB-48 and apoB-100. It would appear that the smaller isoform is responsible for transferring dietary lipids into the blood stream. This may hold a key for understanding possible active sites for lipid production and lipid clearance, and the possible effects of certain mutations in those domains.
For now, I don’t think we need to specifically address Behe’s larger arguments. Rather, we could narrowly focus on understanding the role of ApoB in lipid metabolism.