Glipsnort wrote:
“I don’t believe anyone has suggested that orphan genes are simply artifacts of poor sampling or incomplete genome annotation.”
From the BMC Bioinformatics paper (Arendsee et al. 2019) cited in my post above:
“Most researchers argued then that the uniqueness of these genes was an artifact of sparse sampling or bad gene prediction, and that when enough genomes were sequenced, all correctly annotated genes would cluster into large, ancient families.”