@John_Harshman has waited patiently to discuss trans-species variation and HLA nomenclature with me, after I put it on hold a while ago (John Harshman: Bottlenecks and Trans-Species Variation).
He has argued that there is trans-species variation for more than just 4 alleles at some HLA loci (locations/genes). However, I’m not sure. It seemed that variation I thought was a different loci, @John_Harshman was convinces was actually at the same locus. In the discussion, I was getting pretty confused by HLA nomenclature, because it seemed that @John_Harshman understood it quite differently than me.
This website is helpful:
So @John_Harshman can you please clarify specifically, with references, the evidence for more than 4 lineages of trans-species variation at a single loci? I honestly want to get this straight, and I think that clarifying the HLA nomenclature (which is complex but also tightly regulated) will help us do this.