I have never seen Mendel’s Accountant used to reproduce the curve of relative fitness-gains observed in the LTEE using what Sanford thinks is a realistic DFE of mutations, and the mutation rate for E coli. I’ve tried but couldn’t get the program to run with realistic values. When I tried lowering population size to even make it run, I didn’t see any sustained fitness gains.
Does anyone know of any publication where Sanford shows a curve of fitness gains similar to this one:
-in his MA program when simulating the LTEE using his own DFE of mutations? I just can’t get the damn program to make such a curve of relative fitness gains using Sanford’s DFE.