Mercer's Work on Protein Function and Sequence Space

Continuing the discussion from Gauger and Mercer: Bifunctional Proteins and Protein Sequence Space:

@JAMercer, I’m looking forward to the exchange with @Agauger. Hopefully Doug Axe will join too, as he is the one who has been pushing this work the most in his book, Undeniable. She can’t engage in depth right now, but in the mean time, can you expand on your work here?

Here are some of the summaries you already have:

And one example. Can you explain this paper further, and put the key figures up here too? After, this, what are the next key papers to look at?

I think we should wait until Ann is able to participate.