@Mercer
That’s an interesting example. Using the power of the immune system to search for a protein that binds to a hapten that resembles the transition state of the reaction desired is pretty ingenious. I’d have to read some papers to see how the work was done. But that’s a designed system, making use of an elegant system to target a desired reaction and refine its specificity over time.
As for the last, I would be performing these experiments myself, except I have developed an essential tremor, that gives me shaky hands. I can’t pipet or maintain sterile culture. I haven’t been in the lab for several years.