Came across this interesting article recently. Wonder how a situation where the entire genome effects every complex trait will effect the neutral theory of evolution.
Perhaps @swamidass can comment if he has the time.
Excerpts from the article which describe the concept are below-
The roots of many traits, from how tall you are to your susceptibility to schizophrenia, are far more tangled. In fact, they may be so complex that almost the entire genome may be involved in some way, an idea formalized in a theory put forward last year.
The authors described what they called the “omnigenic” model of complex traits. Drawing on GWAS analyses of three diseases, they concluded that in the cell types that are relevant to a disease, it appears that not 15, not 100, but essentially all genes contribute to the condition. The authors suggested that for some traits, “multiple” loci could mean more than 100,000.