The Argument Clinic

[Roy (34-year veteran)]

@CrisprCAS9

Now, now… it’s point and laugh until Bill shows his math.

Can I also point and laugh after Bill shows his maths?

E.g.:

Even if there are 10^115 different sequences able to adopt the fold the total sequence space is 10^490 so there are 10^385 sequences that do not adopt the fold.

Or:

10^482 is an approximation of 20^371. 2^371 is about 4… e^111. I just approximate to 10^111. Subtract 482-111 and you get 10^371.

Or:

But my answer was about 3x in the exponent too large. The flagellum to fold and bind 30 proteins will take about 2^10000 trials. Translated to the fraction 2^-10000 or 18^10000/20^10000.