Marty's testable ID hypothesis

[John_Harshman]

@Mercer

@Marty

For a protein complex, you need the complement at a “right” location so that the resulting quaternary structure has meaningful catalytic activity.

My point isn’t about right or wrong locations of binding sites. I challenged something much more fundamental and revealing: your claim about how quaternary structure regulates function:

Can you name a single case in biology in which the catalytic activity requires quaternary structure, as it does for all of these human-designed complexes?

There’s a more charitable way to read this. Don’t know if it’s the intended point, but it would be necessary for a complement not to be at the wrong location in order for the quaternary structure to retain catalytic activity, i.e. the binding site must not produce a quaternary structure that blocks access to the active site.